Overview
Venue:
IMB's Seminar Room (2nd floor)
Ackermannweg 4
55128 Mainz
Integrating Mitochondrial Resilience: From Subcellular Stress Signaling to Systemic Aging
"Mitochondria are not only metabolic organelles but also critical signaling hubs that sense cellular perturbations and coordinate adaptive stress responses. My laboratory investigates how mitochondrial dysfunction is detected and communicated across biological scales, from subcellular organelle remodeling to organismal physiology and aging.
In this talk, I will present our recent findings identifying mitochondrial superoxide as a retrograde signal that preserves nuclear envelope integrity through the regulation of lipid metabolism. I will then discuss how localized mitochondrial stress responses can be integrated at the organismal level to influence systemic homeostasis, stress resistance, and longevity.
By linking organelle-level signaling with whole-animal physiology, our work provides new insights into how mitochondrial resilience is established and maintained during aging, and how enhancing such resilience may help delay age-related functional decline."