The Institute of Molecular Biology (IMB)

Welcome to IMB! We are a modern research centre that brings together leading scientists from all over the world. Our researchers tackle ambitious projects at the interface of epigenetics, genome stability, ageing & RNA biology.

About us
Who we are, where we are & what we do...
Research
Our scientists & what they are working on...
Core Facilities
State-of-the-art technologies & services...
Students & Postdocs
Training programmes we offer junior researchers...
Seminars & Events
Conferences, meetings, workshops & more...
Careers
Current opportunities at IMB...

The funds will be used to establish a new doctoral training programme called CoAGE (“Cohorts for Healthy Ageing”)

The conference will be on "The Evil within: Regulation & Repair of Endogenous DNA Damage"

Congratulations to Claudia!

27 Jun 2025
Lecture | Professional Development Lecture
Good scientific practice with Dr Michael Gommel
30 Jun 2025
Course | Professional Skills Course
Think before you write I (Scientific Writing)
Andrew Moore
03 Jul 2025
Seminar | SFB 1361 Seminar
Unravelling DNA repair defects in human disease
Prof. Haico van Attikum
07 Jul 2025
Course | Professional Skills Course
Think before you write II (Scientific Writing)
Andrew Moore

Access the full IMB events calendar by clicking here

Recent Publications

Jun 2025 | ChemMedChem | Stelzl
Proton first: rationalizing a proton transfer in a protein-fragment complex.
Jun 2025 | Genes Dev | Keller Valsecchi
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development.
May 2025 | DNA Repair | Ulrich
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae.
May 2025 | EMBO Rep | Luke
RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres.
May 2025 | Nat Commun | Stelzl | Dormann
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates.
May 2025 | Nat Commun | Dormann
Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3.
May 2025 | J Exp Zool B Mol Dev Evol | Keller Valsecchi
Multiomics reveal associations between CpG methylation, histone modifications and transcription in a…
Apr 2025 | Nat Chem Biol | Dormann
Induced proximity to PML protects TDP-43 from aggregation via SUMO-ubiquitin networks.
Apr 2025 | Curr Opin Struct Biol | Luck
Bias in, bias out - AlphaFold-Multimer and the structural complexity of protein interfaces.
Mar 2025 | Science | Beli
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy.

A centre for basic & clinical research on ageing & age-related disease
with Mainz University & its Medical Center, the Leibniz Institute for Resilience Research & TRON
A joint initiative on the mechanisms underlying robustness & longevity
with groups at Mainz University
A joint PhD programme to discover new ways to understand & treat age-related diseases
with Mainz University & its Medical Center
The largest network on DNA repair & genome stability in Germany
with groups in Mainz, Darmstadt, Frankfurt & Munich
An initiative bridging the polymer & life sciences to understand biological processes such as ageing
with Mainz University, its Medical Center & the Max Planck Institute for Polymer Research
IMB’s flagship PhD training programme on epigenetics, genome stability & ageing
with Mainz University & its Medical Center
A DFG-funded PhD programme on how RNA processes contribute to robustness & resilience
with groups from Mainz University & its Medical Center
A DFG-funded PhD programme on the evolution of gene regulatory networks underlying phenotype & lifespan
with Mainz University’s Faculty of Biology
IMB's summer school on epigenetics & genome stability in health, ageing & disease, for Master & undergraduate students
with Mainz University's Faculty of Biology

News

IMB and the Centre for Healthy Ageing (CHA) receive €1.3 million to study the causes of age-related diseases

Save the date for the IMB/SFB 1361 Conference in March 2026!

Claudia Keller Valsecchi recieves the Friedrich Miescher Award 2025

Upcoming Events

27 Jun 2025

30 Jun 2025

03 Jul 2025

07 Jul 2025

Joint Research Initiatives

A centre for basic & clinical research on ageing & age-related disease

A joint initiative on the mechanisms underlying robustness & longevity

A joint PhD programme to discover new ways to understand & treat age-related diseases

The largest network on DNA repair & genome stability in Germany

An initiative bridging the polymer & life sciences to understand biological processes such as ageing

IMB’s flagship PhD training programme on epigenetics, genome stability & ageing

A DFG-funded PhD programme on how RNA processes contribute to robustness & resilience

A DFG-funded PhD programme on the evolution of gene regulatory networks underlying phenotype & lifespan

IMB's summer school on epigenetics & genome stability in health, ageing & disease, for Master & undergraduate students